PXD062718 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lactylation omics of rabbit rotator cuff tears |
| Description | In this study, we conducted lactylation omics on rabbit rotator cuff tear samples and identified 2624 modification sites on 851 proteins. We obtained results on modification intensity, subcellular localization, modified sites, differentially modified proteins and functional pathway enrichment. Basing on motifs, we proposed the "lysine co-lactylation modification effect" concept. Additionally, we surprisedly found the levels of lactate and lactylation is not perfectly consistent. While lactate continuously increased, lactylation initially decreased and then increased. Overall, lactylation widespreadly occurs and mainly localized in cytoplasm, mitochondria and nucleus, with its functional pathways enriching in RNA processing, DNA processing and cellular metabolism. We hope that lactylation intervention could provide new insights and therapies for the repair of rotator cuff tears. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-05_17:09:00.683.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tong Pan |
| SpeciesList | scientific name: Leporidae; NCBI TaxID: NEWT:9979; |
| ModificationList | lactic acid |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-08 02:12:53 | ID requested | |
| ⏵ 1 | 2026-04-05 17:09:01 | announced | |
Publication List
| Pan T, Liu Z, Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets. Front Med (Lausanne), 13():1797466(2026) [pubmed] |
| 10.3389/fmed.2026.1797466; |
Keyword List
| submitter keyword: Lactate |
| lactylation |
| omics |
Contact List
| Tong Pan |
|---|
| contact affiliation | Peking University Third Hospital |
| contact email | pantong2000@bjmu.edu.cn |
| lab head | |
| Tong Pan |
|---|
| contact affiliation | Peking University Third Hospital |
| contact email | pantong2000@bjmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD062718 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062718
- Label: PRIDE project
- Name: Lactylation omics of rabbit rotator cuff tears
