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PXD062716-1
PXD062716 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Spatially resolved proteomic mapping in skin organoid for hair follicle development |
| Description | Hair follicle development is a complex, highly regulated process involving interactions between epithelial and mesenchymal cells. However, the specific molecular mechanisms and important biological processes of hair follicle development remain poorly understood. In this study, we applied spatially resolved proteomic mapping to investigate the process of hair follicle development in skin organoids at different stages: D55, D75, D90, D140, D150, and D170, which corresponds to that from hair germ formation to hair follicle aging. Our analysis identified dynamic changes in protein expression and active protein synthesis during hair follicle appearance. The results provide a comprehensive spatial proteomic map of hair follicle development and offer new insights into the biological process driving hair follicle formation and maturation. These findings may guide future therapeutic strategies for hair regeneration and the treatment of hair disorders. |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-08 |
| AnnouncementXML | Submission_2026-04-07_02:32:27.089.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jia Zhou |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-08 01:10:13 | ID requested | |
| ⏵ 1 | 2026-04-07 02:32:28 | announced |
Publication List
| Liang L, Zhou J, Wang W, Wang W, Liu Y, Li J, Leng L, Spatially Resolved Proteomic Mapping in Skin Organoid for Hair Follicle Development. Mol Cell Proteomics, 25(1):101482(2026) [pubmed] |
Keyword List
| submitter keyword: Hair follicle, Skin organoid, Spatially resolved proteome, Development |
Contact List
| Ling Leng | |
|---|---|
| contact affiliation | Peking Union Medical College Hospital |
| contact email | lengling@pumch.cn |
| lab head | |
| Jia Zhou | |
| contact affiliation | Peking Union Medical College Hospital |
| contact email | zhou18@student.pumc.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
