⮝ Full datasets listing
PXD062691-1
PXD062691 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Validation of a mass spectrometry-based proteomics molecular pathology assay |
| Description | Amyloidosis is characterized by the deposition of protein fibrils in extra-cellular regions, resulting in the displacement and damage of healthy tissue. These diseases lead to organ damage, dysfunction, and death which is why diagnosis, characterization, and management of the disease are critical. Following a diagnosis of amyloidosis, determination of the causative protein is the next and vital step to proper treatment, as the subtypes differ in pathogenesis and clinical management. There are approximately 30 known causative proteins. Existing methods are lacking and served as motivation for the development of a clinically applicable mass spectrometry-based method for the identification of amyloid causative proteins in FFPE tissue biopsies. This method combines the power of laser microdissection for enrichment of amyloid deposits with the sensitivity and specificity of liquid chromatography mass spectrometry (LCMS). Variations of this original assay have been adapted by several reference laboratories, specialized disease centers, and academic centers and is considered the international gold standard for diagnosis and classification of amyloidosis. The aim of this paper is to outline the general considerations for development, validation, and implementation of a clinical assay with a focus on mass spectrometry-based proteomic assays in molecular and clinical pathology practice. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-13_04:46:55.157.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jessica Chapman-Lim |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Methyl; Formyl; Dimethyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-07 12:10:08 | ID requested | |
| ⏵ 1 | 2026-04-13 04:46:55 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: amyloidosis, FFPE, DatasetType:Proteomics |
Contact List
| Jessica Chapman | |
|---|---|
| contact affiliation | MSKCC |
| contact email | chapmanj@mskcc.org |
| lab head | |
| Jessica Chapman-Lim | |
| contact affiliation | MSKCC |
| contact email | chapmanj@mskcc.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097559/ |
