PXD062674-1

PXD062674 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Global analysis of cancer cell responses to USP9X inhibition
Description	Global proteomics experiment using USP9X siRNA (and control) MDA-MB-231 cells with (10 µM, 24 h) and without USP9X inhibitor treatment using WEHI-092 and untreated (DMSO) control (P5448, see sample key). Global proteomics experiment profiling cancer cell lines treated with USP9X inhibitor WEHI-092 (10 µM, 24 h) and untreated (DMSO) control. P4971 1-5 UO-31 cells, untreated P4971 6-10 UO-31 cells, WEHI-092 P4971 11-15 A549 cells, untreated P4971 16-20 A549 cells, WEHI-092 P4971 21-25 DLD-1 cells, untreated P4971 26-30 DLD-1 cells, WEHI-092 P4971 41-45 OVCAR8 cells, untreated P4971 46-50 OVCAR8 cells, WEHI-092 P4971 51-55 SK-MEL-2 cells, untreated P4971 56-60 SK-MEL-2 cells, WEHI-092 P5080 11-15 HMEC-1 cells, untreated P5080 16-20 HMEC-1 cells, WEHI-092
HostingRepository	PRIDE
AnnounceDate	2026-04-09
AnnouncementXML	Submission_2026-04-09_15:03:10.272.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Philipp Schenk
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro; Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-07 02:35:41	ID requested
⏵ 1	2026-04-09 15:03:11	announced

Publication List

10.1038/s44318-026-00742-y;
Schenk P, Devine SM, Cobbold SA, Geoghegan ND, Kyran EL, Ang CS, Alexandrovics JA, Calleja DJ, Multari DH, Vaibhav V, Lu BGC, Klemm TA, Dagley LF, Lowes KN, Williamson NA, Eichhorn PJA, Ng AP, Feltham R, Komander D, Global analysis of cancer cell responses to USP9X inhibition. EMBO J, 45(9):3306-3331(2026) [pubmed]

10.1038/s44318-026-00742-y;

Schenk P, Devine SM, Cobbold SA, Geoghegan ND, Kyran EL, Ang CS, Alexandrovics JA, Calleja DJ, Multari DH, Vaibhav V, Lu BGC, Klemm TA, Dagley LF, Lowes KN, Williamson NA, Eichhorn PJA, Ng AP, Feltham R, Komander D, Global analysis of cancer cell responses to USP9X inhibition. EMBO J, 45(9):3306-3331(2026) [pubmed]

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

David Komander
contact affiliation	Head, Ubiquitin Signalling Division Walter and Eliza Hall Institute of Medical Research Australia
contact email	dk@wehi.edu.au
lab head
Philipp Schenk
contact affiliation	WEHI
contact email	schenk.p@wehi.edu.au
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD062674
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD062674

PRIDE project URI

Repository Record List

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