PXD062668-2

PXD062668 is an original dataset announced via ProteomeXchange.

Title	Integrated Plasma and Vegetation Proteomic Characterization of Infective Endocarditis for Early Diagnosis and Treatment
Description	Infective endocarditis, a life-threatening condition, poses significant challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we analyzed plasma and vegetation proteomes from 238 patients with infective endocarditis and 100 controls, with two external validation cohorts. We developed machine learning-based diagnostic and prognostic models for infective endocarditis, with area under the curve values of 0.98 and 0.87, respectively. Leucine-rich alpha-2-glycoprotein 1 and NADH:ubiquinone oxidoreductase subunit B4 are potential biomarkers associated with infection severity. Pathologically, protein networks characterized by glycometabolism, amino acid metabolism, and adhesion are linked to adverse events. Liver dysfunction may exacerbate the condition in patients with severe heart failure. Neutrophil extracellular traps emerge as promising therapeutic targets in Streptococcus or Staphylococcus aureus infections. Collectively, our findings provide significant insights into biomarker discovery and underlying pathophysiological mechanisms in infective endocarditis, advancing early diagnosis and personalized medicine.
HostingRepository	iProX
AnnounceDate	2025-04-06
AnnouncementXML	Submission_2025-06-04_00:14:56.382.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shiman He
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-07 00:26:07	ID requested
1	2025-04-07 00:27:23	announced
⏵ 2	2025-06-04 00:14:57	announced	2025-06-04: Add Publication.

He S, Hu X, Zhu J, Wang W, Ma C, Ran P, Chen O, Chen F, Qing H, Ma J, Zeng D, Wang Y, Liu W, Feng J, Gan L, Qin Z, Tan S, Tian S, Ding C, Jian X, Gu B, Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment. Nat Commun, 16(1):5052(2025) [pubmed]

submitter keyword: IE, Proteomics, LRG1, NETs, NYHA, Streptococcus

Chen Ding
contact affiliation	Fudan University
contact email	chend@fudan.edu.cn
lab head
Shiman He
contact affiliation	Fudan University
contact email	21112030018@m.fudan.edu.cn
dataset submitter

iProX dataset URI