PXD062631-1

PXD062631 is an original dataset announced via ProteomeXchange.

Title	Examining differential protein expression in brain and retinal tissue from the Mthfr677C>T mouse model
Description	The Mthfr677C>T variant is associated with Alzheimer's disease and vascular dementia. We created a knockin mouse model containing the variant and have been characterizing brain and retinal health in the mice, with special focus on vascular dysfunction. We have shown similar vascular phenotypes in the two tissues and wanted to assess differential protein expression in each tissue by genotype. We were then able to compare which proteins are changing in tandem and determine associated and relevant pathways; these data will help direct the next stage of study.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-25_03:41:54.135.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD062631
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michael MacLean
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-04 15:19:44	ID requested
⏵ 1	2025-08-25 03:41:55	announced

10.6019/PXD062631;

Reagan AM, MacLean M, Cossette TL, Howell GR, mouse model of cerebrovascular disease. Alzheimers Dement, 21(8):e70501(2025) [pubmed]

10.1002/alz.70501;

submitter keyword: vascular contributions to cognitive impairment and dementia (VCID),Mouse model characterization, brain, neurovascular dysfunction, retina

Gareth Howell
contact affiliation	Professor, Diana Davis Spencer Foundation Chair for Glaucoma Research, The Jackson Laboratory
contact email	gareth.howell@jax.org
lab head
Michael MacLean
contact affiliation	The Jackson Laboratory
contact email	michael.maclean@jax.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD062631

PRIDE project URI

• PRIDE
  1. PXD062631
     1. Label: PRIDE project
     2. Name: Examining differential protein expression in brain and retinal tissue from the Mthfr677C>T mouse model