PXD062530-1

PXD062530 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of bone marrow CD138+ cells to identify proteins associated with the response of multiple myeloma patients to commonly used therapeutic regimens.
Description	Multiple Myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs resistance mechanisms are involved in the failure of therapies to eradicate the disease. This study aims to identify proteins significantly impacting MM patients' response to commonly used therapeutic regimens. Bone marrow CD138+ selected plasma cells were isolated from patients that had achieved Response (Responders, R) and those who were Non-Responders (NR) to their primary MM therapy. We used LC-MS/MS to investigate the proteomic profile of MM samples, followed by statistical and bioinformatics analysis. Collectively, proteomics data obtained from R and NR to MM therapy displayed significant changes in the immune system and protein synthesis regulation, supporting their potential role in progression and therapeutic response of MM.
HostingRepository	MassIVE
AnnounceDate	2025-09-01
AnnouncementXML	Submission_2025-09-01_06:06:31.864.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manousos Makridakis
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-02 09:17:23	ID requested
⏵ 1	2025-09-01 06:06:32	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Biomarkers, Cancer, Multiple Myeloma, Proteomics, Therapy, DatasetType:Proteomics

submitter keyword: Biomarkers, Cancer, Multiple Myeloma, Proteomics, Therapy, DatasetType:Proteomics

Contact List

Jerome Zoidakis
contact affiliation	BRFAA
contact email	izoidakis@bioacademy.gr
lab head
Manousos Makridakis
contact affiliation	Biomedical Research Foundations, Academy of Athens
contact email	mmakrid@bioacademy.gr
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097497/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097497/