⮝ Full datasets listing
PXD062480-1
PXD062480 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative growth and proteomic analysis of Gardnerella leopoldii, G. Piotii and G. vaginalis biofilms |
| Description | Despite the high global burden of bacterial vaginosis (BV) and its negative reproductive sequelae, its pathogenesis remains obscure. Until recently, the Gardnerella genus which has been proposed to play a pivotal role in BV pathogenesis likely via biofilm initiation, was considered monotypic. This paradigm shifted with the recognition of species heterogeneity within the Gardnerella genus. Here, biofilm growth and proteomes of three Gardnerella species isolates G. vaginalis, G. leopoldii, and G. piotii were examined. Important findings included cysteine synthase (cysK) being identified among the top upregulated proteins in the robust biofilms produced by G. leopoldii and G. piotii compared to G. vaginalis, which produced biofilms of significantly lower biomass and viability. Proteomic analysis identified significant differences in functional pathways and virulence proteins. By identifying potential drivers of differential biofilm formation among these different Gardnerella species, this study underscores the significance of Gardnerella heterogeneity in the understanding of BV pathogenesis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-10 |
| AnnouncementXML | Submission_2026-07-10_04:16:38.476.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Elinor Shvartsman |
| SpeciesList | scientific name: Gardnerella vaginalis; NCBI TaxID: 2702; |
| ModificationList | L-methionine sulfoxide |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-01 13:45:08 | ID requested | |
| ⏵ 1 | 2026-07-10 04:16:38 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: bacterial vaginosis, proteomics, DatasetType:Proteomics |
Contact List
| Paul Sandstrom | |
|---|---|
| contact affiliation | National Microbiology Laboratory |
| contact email | paul.sandstrom@phac-aspc.gc.ca |
| lab head | |
| Kelly MacDonald | |
| contact affiliation | University of Manitoba |
| contact email | kelly.macdonald@umanitoba.ca |
| lab head | |
| Elinor Shvartsman | |
| contact affiliation | University of Manitoba |
| contact email | Shvartse@myumanitoba.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097483/ |
