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PXD062448-1
PXD062448 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pro DIA-quantitative proteomics analysis reveals the mechanism of ganoderma lucidum spore oil suppressing tumor growth in hepatoma H22-bearing mice |
| Description | Ganoderma lucidum spore oil (GLSO) is a well-known dietary supplement that is beneficial for immunoenhancement and shows good antitumor efficacy. However, the anti-tumor mechanism of GLSO remains unclear. Three tumor samples were randomly taken from model group mice and H-GLSO group mice, and the experimental operations were performed. The results revealed that 340 proteins were upregulated and 599 proteins were downregulated after treatment with GLSO . WikiPathway enrichment analysis of the differentially expressed proteins revealed that the lipoxygenase (LOX), cyclooxygenase (COX) and cytochrome P450 (P450) mediated eicosanoid metabolism pathways in tumor tissues were significantly inhibited after treatment with GLSO. Further statistical analysis of the differentially expressed proteins in the eicosanoid metabolism pathway was conducted to visualize the relevant results. The results showed that after intervention with GLSO, key proteins of the eicosanoid metabolism pathway, including the Gpx1, Lta4h, Ephx2, Alox15, Alox5, Ptgr1, Cyp4f3, Cyp4f14, Ggt5, Acox3, Ptgs1, Tbxas1, Pla2g4a, and Cyp2j5 were significantly downregulated in the tumor tissues of hepatoma H22-bearing mice treated with GLSO. |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-01 |
| AnnouncementXML | Submission_2026-04-08_00:21:27.091.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xueqian Xie |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-01 01:15:46 | ID requested | |
| ⏵ 1 | 2026-04-08 00:21:27 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ganoderma lucidum spore oil, tumor tissue, hepatoma H22-bearing mice |
Contact List
| Qing Wang | |
|---|---|
| contact affiliation | Guangzhou University of Chinese Medicine |
| contact email | wangqing@gzucm.edu.cn |
| lab head | |
| Xueqian Xie | |
| contact affiliation | Guangzhou University of Chinese Medicine |
| contact email | xxq_gzucm@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
