PXD062393-1

PXD062393 is an original dataset announced via ProteomeXchange.

Title	Study on the in vivo binding targets of jolkinolide B and its anti-tumor mechanisms
Description	Pancreatic cancer remains a highly malignant disease with limited effective treatment options. Covalent-binding drugs have received substantial attention due to their high specificity, selectivity, and low resistance potential. In this study, we demonstrated that jolkinolide B (JB), a natural epoxide compound, exerts potent anti-tumor effects against pancreatic cancer both in vitro and in vivo. By utilizing high-resolution protein identification and quantitative technology of mass spectrometry, we revealed the logical relationship between JB, target, mechanism, and phenotype, which makes JB a promising lead compound for further drug development.
HostingRepository	iProX
AnnounceDate	2025-03-30
AnnouncementXML	Submission_2025-03-31_01:31:39.092.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mingjie Gao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-31 01:31:16	ID requested
⏵ 1	2025-03-31 01:31:39	announced

Dataset with its publication pending

submitter keyword: Jolkinolide B, Covalent-binding, Drug targets, Anti-tumor mechanisms

Jianguo Ji
contact affiliation	Peking University
contact email	jijg@pku.edu.cn
lab head
Mingjie Gao
contact affiliation	Peking University
contact email	gaomingjie@stu.pku.edu.cn
dataset submitter

iProX dataset URI