PXD062384-1

PXD062384 is an original dataset announced via ProteomeXchange.

Title	Human Femoral Artery Proteome and 2-Hydroxyisobutyrylation Analysis in Metabolic Syndrome Induced Restenosis
Description	Restenosis is the primary complication following stenting for coronary and peripheral arterial disease (PAD), posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as an independent predictor for postoperative restenosis in coronary and carotid arteries, potentially due to endothelial dysfunction and augmented oxidative stress in cells, while its specific regulatory mechanism is still largely unknown. Lysine 2-hydroxyisobutyrylation (Khib), a recently identified post-translational modification, plays a crucial role in transcriptional regulation and cellular metabolism. However, there is a lack of comprehensive analysis of the proteome and Khib modifications within restenotic vessels in the context of MetS, as well as in the understanding of the associated pathophysiology. Here, we firstly validate changes in expression and distribution of Khib in vascular tissues in clinical tissue and cell models. Subsequently, we utilized proteomics and modifiomics to examine the protein and Khib modification characteristics in MetS-induced restenosis.
HostingRepository	PRIDE
AnnounceDate	2025-06-23
AnnouncementXML	Submission_2025-06-22_16:16:06.787.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongxin Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	butanoylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-30 20:09:26	ID requested
⏵ 1	2025-06-22 16:16:07	announced

10.1016/j.mcpro.2025.100978;

Liu X, Zhou L, Huang W, Yang Y, Yang Y, Liu T, Guo M, Yu T, Li Y, Proteomic Analysis and 2-Hydroxyisobutyrylation Profiling in Metabolic Syndrome Induced Restenosis. Mol Cell Proteomics, 24(6):100978(2025) [pubmed]

submitter keyword: Restenosis

metabolic syndrome

proteomics

Yongxin Li
contact affiliation	The Affiliated Hospital of Qingdao University
contact email	alexander1985827@163.com
lab head
Yongxin Li
contact affiliation	The Affiliated Hospital of Qingdao University
contact email	alexander1985827@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD062384

PRIDE project URI

• PRIDE
  1. PXD062384
     1. Label: PRIDE project
     2. Name: Human Femoral Artery Proteome and 2-Hydroxyisobutyrylation Analysis in Metabolic Syndrome Induced Restenosis