PXD062328-1

PXD062328 is an original dataset announced via ProteomeXchange.

Title	Evolutionary Trajectories of IDH-Mutant Astrocytoma Identify Molecular Grading Markers Related to Cell Cycling
Description	To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent tumor samples using genetic, epigenetic, transcriptomic and proteomic profiling combined with single-cell analysis.
HostingRepository	PRIDE
AnnounceDate	2025-07-08
AnnouncementXML	Submission_2025-07-08_14:00:48.396.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marcel Bühler
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-27 19:40:42	ID requested
⏵ 1	2025-07-08 14:00:48	announced

10.1038/S43018-025-01023-Z;

submitter keyword: single-cell, IDH mutant, Multi-omics, treatment resistance, DNA methylation,Astrocytoma

Tobias Weiss
contact affiliation	Department of Neurology, University Hospital of Zurich (USZ) and University of Zurich (UZH)
contact email	Tobias.Weiss@usz.ch
lab head
Marcel Bühler
contact affiliation	VIB-UGent Center for Medical Biotechnology
contact email	marcel.buehler@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD062328

PRIDE project URI

• PRIDE
  1. PXD062328
     1. Label: PRIDE project
     2. Name: Evolutionary Trajectories of IDH-Mutant Astrocytoma Identify Molecular Grading Markers Related to Cell Cycling