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PXD062291-1

PXD062291 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Catalytic mechanism of an Actin-dependent adenylyltransferase involved in ubiquitin signaling
Description	The two effectors LnaB and MavL of Legionella pneumophila coordinate the conversion of phosphoribosyl ubiquitin (PR-Ub) released by reversal of ubiquitination induced by members of the SidE effector family into functional Ub. LnaB acts as an actin-dependent phosphoryl AMPylase that converts PR-Ub into ADP-ribosylated (ADPR)-Ub. Catalysis by LnaB requires the novel conserved S-HxxxE motif present in a large family of bacterial toxins. Here we uncovered a novel adenylylation mechanism involved in two-step ATP hydrolysis.
HostingRepository	iProX
AnnounceDate	2025-03-27
AnnouncementXML	Submission_2025-03-26_23:37:57.534.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaqi Fu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-26 23:35:46	ID requested
⏵ 1	2025-03-26 23:37:57	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Protein AMPylation

Contact List

Jiaqi Fu
contact affiliation	The First Hospital of Jilin University
contact email	fujiaqi@jlu.edu.cn
lab head
Jiaqi Fu
contact affiliation	The First Hospital of Jilin University
contact email	fujiaqi@jlu.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI