PXD062245-2

PXD062245 is an original dataset announced via ProteomeXchange.

Title	Investigating the off-target effects of Pro-BA using label-free and TMTpro quantitative proteomics
Description	Nevertheless, in-depth characterization of the proteome could reveal unknown off-targets of Pro-BA. To address this issue, we repeated the same experiment but extended MS analysis time to 2 hours in this revision, which will be elaborated in the next point. Nonetheless, the computed p-value of ALK p-value is less than 0.05, with and without FDR correction, with the new dataset.
HostingRepository	iProX
AnnounceDate	2025-03-25
AnnouncementXML	Submission_2025-07-08_22:42:56.130.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fengming Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-25 23:26:19	ID requested
1	2025-03-25 23:26:48	announced
⏵ 2	2025-07-08 22:42:56	announced	2025-07-09: Add info.

Zhang J, Chen C, Chen X, Liao K, Li F, Song X, Liu C, Su MY, Sun H, Hou T, Tan CSH, Fang L, Rao H, Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun, 16(1):4794(2025) [pubmed]

submitter keyword: Labelfree, TMTpro label, 2h gradient, PD2.4

Soonheng Tan
contact affiliation	Southern University of Science and Technology
contact email	christan@sustech.edu.cn
lab head
Fengming Li
contact affiliation	Southern University of Science and Technology
contact email	12331077@mail.sustech.edu.cn
dataset submitter

iProX dataset URI