PXD062164-1

PXD062164 is an original dataset announced via ProteomeXchange.

Title	Hypertrophic cardiomyocytes promote breast cancer progression through exosomal miRNA and proteins
Description	Evidence from epidemiological and mechanistic studies suggests that a variety of cardiovascular diseases are associated with tumour development. However, which cell types in the diseased heart are involved in the promotion of tumour progression remains poorly understood. In this study, the role of exosomes from hypertrophic cardiomyocytes in tumour progression was investigated. A model of cardiac hypertrophy was generated in mice using transverse aortic constriction (TAC). Breast cancer cells were then implanted in model animals. Exosomes derived from AC16 cardiomyocytes treated with Ang II to induce hypertrophic growth were subsequently injected into nude mice in which breast cancer cells had previously been implanted. The results showed that exosomes from hypertrophic cardiomyocytes promoted breast cancer progression. Furthermore, transcriptome sequencing and mass spectrometric analysis demonstrated that miR-362-5p, S100A7, and S100A8 were upregulated in exosomes derived from Ang II-treated AC16 cells, which promoted the proliferation, invasion, and migration of breast cancer cells. A retrospective clinical study showed that the expression of miR-362-5p, S100A7, and S100A8 was increased in plasma exosomes obtained from patients with cardiac hypertrophy. Notably, the levels of the three factors were observed to be associated with the extent of inflammation in patients with myocardial hypertrophy. Hypertrophic cardiomyocytes promote breast cancer progression through exosomes, and this effect is mediated by S100A7, S100A8, and miRNA-362-5p contained in the exosomes released from these cells.
HostingRepository	PRIDE
AnnounceDate	2026-03-24
AnnouncementXML	Submission_2026-03-24_06:15:06.883.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Hu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-24 01:24:22	ID requested
⏵ 1	2026-03-24 06:15:07	announced

Dataset with its publication pending

submitter keyword: breast cancer, GW4869, S100A7, S100A8,cardiac hypertrophy, miR-362-5p

Xin Hu
contact affiliation	China-Japan Union Hospital of Jilin University
contact email	huxin@jlu.edu.cn
lab head
Xin Hu
contact affiliation	China-Japan Union Hospital of Jilin University
contact email	huxin@jlu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD062164

PRIDE project URI

• PRIDE
  1. PXD062164
     1. Label: PRIDE project
     2. Name: Hypertrophic cardiomyocytes promote breast cancer progression through exosomal miRNA and proteins