PXD062013-1

PXD062013 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis after interference with TERC in bladder cancer cell line
Description	Muscle-invasive bladder cancer is closely associated with the susceptibility to metastasis and poor prognosis. In recent years, numerous studies have revealed that certain long non-coding RNAs (lncRNAs) may be involved in malignant progression of tumors. Here, we identified a lncRNA, telomerase RNA component (TERC), that is significantly upregulated in invasive bladder urothelial carcinoma tissues. We used in vitro and in vivo models to demonstrate its oncogenic effects. Mechanistically, we screened out the PPAR signaling pathway (RXRA, FABP3) regulated by TERC through proteomics and enrichment analysis.
HostingRepository	PRIDE
AnnounceDate	2025-06-24
AnnouncementXML	Submission_2025-06-23_19:42:40.047.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chen Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-18 22:21:11	ID requested
⏵ 1	2025-06-23 19:42:40	announced

Dataset with its publication pending

submitter keyword: Human, bladder cancer, TERC, LC-MS/MS

Chen Chen
contact affiliation	Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
contact email	1831221@tongi.edu.cn
lab head
Chen Chen
contact affiliation	Tongji University
contact email	1831221@tongji.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD062013

PRIDE project URI

• PRIDE
  1. PXD062013
     1. Label: PRIDE project
     2. Name: Proteomic analysis after interference with TERC in bladder cancer cell line