PXD061961 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MS-based proteomics in HUVECs transfecting with IVT mRNA |
| Description | The therapeutic success of in vitro-transcribed (IVT) mRNA depends on its stability and efficient translation. However, IVT mRNA is highly susceptible to immune-mediated degradation, limiting its efficacy. To investigate the binding protein profiles of IVT mRNA, we transfected HUVECs with 4SU-modified mRNA for 6h. LC-MS/MS was performed to identify the binding proteins of IVT mCherry mRNA. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-23_00:06:32.438.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xing Peng |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-18 00:49:39 | ID requested | |
| ⏵ 1 | 2026-03-23 00:06:32 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LC-MS/MS, HUVECs, IVT mRNA |
Contact List
| Shu Meng |
|---|
| contact affiliation | Meng Lab, Department of Basic Research, Guangzhou National Laboratory, No.9, XingDaoHuanBei Road, Guangzhou International Bio-island, Haizhu District Guangzhou, Guangdong, 510005, China |
| contact email | meng_shu@gzlab.ac.cn |
| lab head | |
| Xing Peng |
|---|
| contact affiliation | Guangzhou National Laboratory |
| contact email | peng_xing@gzlab.ac.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD061961 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061961
- Label: PRIDE project
- Name: MS-based proteomics in HUVECs transfecting with IVT mRNA
