PXD061918-1

PXD061918 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human endosomal proximity proteome
Description	Here, using comparative proximity proteomics of critical retrieval sub-domain components Retromer and Retriever, their cargo adaptors, and a component of the opposing ESCRT-degradative sub-domain, we provide a data-rich resource that identifies new molecular details of retrieval sub-domain composition and organization, including an unrecognised complexity in the interface of Retromer with RAB GTPases.
HostingRepository	PRIDE
AnnounceDate	2025-08-22
AnnouncementXML	Submission_2025-08-22_01:10:06.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carlos Anton-Plagaro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Proteome Discoverer; Orbitrap Fusion; Xcalibur

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-17 06:33:30	ID requested
⏵ 1	2025-08-22 01:10:07	announced

Publication List

10.1038/s41467-025-61802-1;
Ant, ó, n-Pl, á, garo C, Chen KE, Guo Q, Liu M, Evans AJ, Lewis PA, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ, Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. Nat Commun, 16(1):6990(2025) [pubmed]

10.1038/s41467-025-61802-1;

Ant, ó, n-Pl, á, garo C, Chen KE, Guo Q, Liu M, Evans AJ, Lewis PA, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ, Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. Nat Commun, 16(1):6990(2025) [pubmed]

Keyword List

submitter keyword: HeLa, Proximity proteomics, Endosomes, TMT label, LC-MS/MS

submitter keyword: HeLa, Proximity proteomics, Endosomes, TMT label, LC-MS/MS

Contact List

Peter J. Cullen
contact affiliation	Cullen Laboratory School of Biochemistry University of Bristol, UK
contact email	pete.cullen@bristol.ac.uk
lab head
Carlos Anton-Plagaro
contact affiliation	University of Bristol
contact email	carlos.antonplagaro@bristol.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD061918
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD061918

PRIDE project URI

Repository Record List

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