PXD061867 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Defining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry. |
| Description | Among the strongest associations with pediatric B-cell acute lymphoblastic leukemia (B-ALL) are risk non-coding variants localized in the intron of ARID5B (AT-rich interaction domain 5B), a poorly characterized DNA-binding protein. In this study, we defined the interactome of ARID5B by LC-MS/MS and identified transcriptional repressors HDAC1, HDAC2, MIER1 and C16ORF87 as interactors. Structural predictions revealed that ARID5B and its interactors assemble into a repressor complex. We further validated and characterized the molecular function of the ARID5B repressor complex in B cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-19_13:13:07.960.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fabian Frommelt |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-14 16:38:12 | ID requested | |
| ⏵ 1 | 2026-05-19 13:13:08 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: transcriptional repressor complex,AviTag |
Contact List
| Davide Seruggia |
|---|
| contact affiliation | St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. |
| contact email | davide.seruggia@ccri.at |
| lab head | |
| Fabian Frommelt |
|---|
| contact affiliation | CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences |
| contact email | fabian.frommelt@hotmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD061867 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061867
- Label: PRIDE project
- Name: Defining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry.
