PXD061817-1

PXD061817 is an original dataset announced via ProteomeXchange.

Title	Overload of Neprilysin in Placental Extracellular Vesicles Disrupts CNP-NPRB-Mediated Communication between Vascular Endothelial and Smooth Muscle Cells: A Trigger for Symptoms of Preeclampsia
Description	Preeclampsia (PE) is a placenta-origin pregnancy complication. Although its development has long been divided into two stages: abnormal placentation (stage I) and the release of factors from the hypoperfused placenta into circulation, triggering PE due to endothelial dysfunction (stage II), the placenta-derived substances coupling the two stages remain unclear.Excessive NEP in PEPL-EVs is transported into the endothelial cells of uterine and placental arteries to cleave and degrade CNP, resulting in compromised CNP paracrine activity and NPR-B-mediated cGMP production in adjacent VSMCs and triggering the hypertensive manifestation of PE.
HostingRepository	iProX
AnnounceDate	2025-03-14
AnnouncementXML	Submission_2025-03-13_23:58:29.367.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Du
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-13 23:58:06	ID requested
⏵ 1	2025-03-13 23:58:29	announced

Dataset with its publication pending

submitter keyword: extracellular vesicles, neprilysin, preeclampsia, C-type natriuretic peptide, endothelial dysfunction

Chao Tong
contact affiliation	Children's Hospital of Chongqing Medical University
contact email	chaotongcqmu@163.com
lab head
Yi Du
contact affiliation	Chongqing Medical University
contact email	513442158@qq.com
dataset submitter

iProX dataset URI