PXD061702 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Large-scale discovery, analysis, and design of protein energy landscapes |
| Description | This dataset supports a multiplexed hydrogen-deuterium exchange mass spectrometry (mHDX-MS) study investigating protein energy landscapes across hundreds of protein domains. Proteins continuously fluctuate between their native states and higher-energy conformations that influence stability, interactions, aggregation, and immunogenicity. However, these excited states remain difficult to characterize experimentally, limiting the development of predictive models for conformational energy landscapes. These data provide a foundation for machine learning approaches to predict protein energy landscapes and enhance biophysical modeling of protein folding and conformational dynamics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_23:03:06.051.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Allan Ferrari |
| SpeciesList | scientific name: mixed DNA libraries; NCBI TaxID: NEWT:1145094; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | SYNAPT G2-Si |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-11 07:31:51 | ID requested | |
| ⏵ 1 | 2026-05-24 23:03:06 | announced | |
Publication List
Keyword List
| submitter keyword: multiplex, hydrogen-deuteuterium exchange, mHDX, large scale,HDX |
Contact List
| Gabriel J Rocklin |
|---|
| contact affiliation | Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Center for Synthetic Biology, Northwestern University, Evanston, IL, USA |
| contact email | grocklin@northwestern.edu |
| lab head | |
| Allan Ferrari |
|---|
| contact affiliation | Department of Pharmacology, Northwestern University |
| contact email | ajrferrari@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD061702 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061702
- Label: PRIDE project
- Name: Large-scale discovery, analysis, and design of protein energy landscapes
