PXD061679-1

PXD061679 is an original dataset announced via ProteomeXchange.

Title	A Comparative Serum Proteomic Analysis in Large-Artery Atherosclerosis Patients Progressing to Acute Ischemic Stroke: Discovery of Predictive Biomarker Panels
Description	To predict acute ischemic stroke (AIS) in large-artery atherosclerosis (LAA), we combined serum proteomics with machine learning to identify diagnostic biomarkers. Using a dual-cohort design, we analyzed proteins and validated targets through advanced proteomic techniques. Machine learning identified two protein panels: one distinguishing AIS from LAA and another differentiating AIS/LAA from healthy controls. These panels capture dynamic pathophysiological processes, offering scalable tools for stroke prediction in high-risk LAA populations, surpassing conventional anatomical assessments.
HostingRepository	iProX
AnnounceDate	2025-03-11
AnnouncementXML	Submission_2025-03-10_22:45:06.965.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yueting Xiong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-10 22:43:58	ID requested
⏵ 1	2025-03-10 22:45:07	announced

Dataset with its publication pending

submitter keyword: Large-artery atherosclerosis, Ischemic stroke, Serum proteomics, Biomarker panel, Risk stratification

Ningshao Xia
contact affiliation	State Key Laboratory of Vaccines for InfectiousDiseases, Xiang AnBiomedicine Laboratory
contact email	nsxia@xmuedu.cn
lab head
Yueting Xiong
contact affiliation	Xiang An Biomedicine Laboratory
contact email	ytxiong@xmu.edu.cn
dataset submitter

iProX dataset URI