PXD061655-1

PXD061655 is an original dataset announced via ProteomeXchange.

Title	SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
Description	• Activating mutations of Shp2 cause conditions such as Noonan syndrome and juvenile myelomonocytic leukemia (JMML), with unmet therapeutic needs. • SFX-01, a sulforaphane complex, modifies cysteine residues and targets proteins including Shp2, where it induces an inhibitory modification at the active site of this protein phosphatase. • In a transgenic mouse model of Noonan syndrome and human JMML stem cells, SFX-01 normalized Shp2 activity, reduced myeloid cell counts, and induced cell-cycle arrest, highlighting its therapeutic potential.
HostingRepository	PRIDE
AnnounceDate	2025-06-12
AnnouncementXML	Submission_2025-06-12_06:14:58.615.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD061655
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Vinothini Rajeeve
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-10 09:19:40	ID requested
⏵ 1	2025-06-12 06:14:59	announced

10.6019/PXD061655;

submitter keyword: Shp2, SFX-01, myeloid cell proliferation, Noonan syndrome, phosphoproteomics, LC-MS/MS

Professor Pedro Cutillas
contact affiliation	BCI Mass Spectrometry Facility 10,2 &1.03 First Floor John Vane Science Centre Bars Cancer Institute, Queen Mary Charterhouse square London EC1M 6BQ
contact email	p.cutillas@qmul.ac.uk
lab head
Vinothini Rajeeve
contact affiliation	Centre for Haemato Oncology
contact email	v.rajeeve@qmul.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD061655

PRIDE project URI

• PRIDE
  1. PXD061655
     1. Label: PRIDE project
     2. Name: SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2