PXD061637-1

PXD061637 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
Description	To explore whether creatine regulates iron death sensitivity in colorectal cancer by modulating the function of certain proteins, we performed immunoprecipitation experiments with biotin-labelled creatine and conducted proteomics studies on these IP-down proteins.
HostingRepository	PRIDE
AnnounceDate	2025-09-06
AnnouncementXML	Submission_2025-09-05_18:48:46.521.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	zhou xiaojun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-10 02:00:07	ID requested
⏵ 1	2025-09-05 18:48:47	announced

Publication List

10.1016/j.celrep.2025.116139;
Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C, Li Y, SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. Cell Rep, 44(9):116139(2025) [pubmed]

10.1016/j.celrep.2025.116139;

Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C, Li Y, SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. Cell Rep, 44(9):116139(2025) [pubmed]

Keyword List

submitter keyword: Tumor metabolic reprogramming
Ferroptosis
Creatine
Immunotherapy

submitter keyword: Tumor metabolic reprogramming

Ferroptosis

Creatine

Immunotherapy

Contact List

Li Youjun
contact affiliation	College of Life Science, Wuhan university, China
contact email	liy7@whu.edu.cn
lab head
zhou xiaojun
contact affiliation	Wuhan University
contact email	2020202040131@whu.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD061637
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD061637

PRIDE project URI

Repository Record List

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