PXD061565-1

PXD061565 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry analysis of post-translational modifications of K/C-III-expressing HEK293T cells treated by A485 for 6 and 12 hours
Description	To determine whether CBP/P300 HAT activity is essential for leukemia cell maintenance, we utilized the selective acetyltransferase inhibitor A485. Mass spectrometry analysis of post-translational modifications showed that A485 treatment of K/C-III-expressing HEK293T cells for 6 and 12 hours significantly reduced multiple histone acetylation marks.
HostingRepository	PRIDE
AnnounceDate	2025-08-08
AnnouncementXML	Submission_2025-08-08_00:41:11.250.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junhui Lv
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-06 22:54:43	ID requested
⏵ 1	2025-08-08 00:41:11	announced

Dataset with its publication pending

submitter keyword: Human, A485, Post-translational modification, K/C-III, LC-FAIMS-MS/MS

Kaiwei Liang
contact affiliation	Department of pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China
contact email	KWliang@whu.edu.cn
lab head
Junhui Lv
contact affiliation	Wuhan University
contact email	lvjunhui@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD061565

PRIDE project URI

• PRIDE
  1. PXD061565
     1. Label: PRIDE project
     2. Name: Mass spectrometry analysis of post-translational modifications of K/C-III-expressing HEK293T cells treated by A485 for 6 and 12 hours