PXD061501 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of the DPP-4 inhibitor Linagliptin on Heart Proteome in Mice Fed Normal and High Fat Diets: Gender-Related Metabolic Responses |
| Description | The dipeptidyl peptidase-4 (DPP-4) inhibitor Linagliptin is known for its role in glucose metabolism and potential cardioprotective effects. This study investigated the cardiac proteome of male and female C57BL/6N mice fed either a normal or high-fat diet, with or without Linagliptin treatment, using a label-free proteomic approach. The analysis revealed significant sex-related metabolic responses, affecting lipid metabolism, oxidative stress, and insulin signaling pathways. Notably, Linagliptin modulated mitochondrial and inflammatory processes, suggesting a potential role in improving cardiac function in obesity. These findings highlight novel biomarkers and molecular mechanisms underlying the cardiometabolic effects of DPP-4 inhibition. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-28 |
| AnnouncementXML | Submission_2026-08-28_10:45:55.821.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Simona Nonnis |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-05 06:49:16 | ID requested | |
| ⏵ 1 | 2026-08-28 10:45:56 | announced | |
Publication List
Keyword List
| submitter keyword: Proteomics, nano LC-MS/MS |
Contact List
| elisa maffioli |
|---|
| contact affiliation | DIVAS, Department of Veterinary Medicine and Animal Science |
| contact email | elisa.maffioli@unimi.it |
| lab head | |
| Simona Nonnis |
|---|
| contact affiliation | University of Milan |
| contact email | simona.nonnis@unimi.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061501
- Label: PRIDE project
- Name: Effect of the DPP-4 inhibitor Linagliptin on Heart Proteome in Mice Fed Normal and High Fat Diets: Gender-Related Metabolic Responses
