PXD061492 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Decoding the molecular complexity governing corneal wound closure in vivo |
| Description | The cornea is the transparent tissue on the anterior surface of the eye. It is notably composed of a squamous stratified epithelium that forms a barrier protecting the ocular chamber. As the cornea is avascular, the delivery of nutrients and growth factors, required for corneal physiology, is essential. These nutrients and factors come from 1) the epithelium itself, 2) the innervation, and 3) the tear film, which together form the corneal microenvironment. Disturbances of this microenvironment, in the context of injury, aging or corneal pathology, can lead to progressive corneal opacification, resulting in blindness. More than 28 million people suffer from mono- or bilateral corneal blindness, making it the fourth cause of blindness worldwide. Corneal abrasion is the most common eye injury encountered in clinics, but poorly studied, making it a major issue in ophthalmology. It is characterized by a transient rupture in the integrity and cellular cohesion of the epithelial barrier, which are brought back thanks to a corneal wound healing process. The aim of this study is therefore to highlight the molecular impact of corneal abrasion on the microenvironment, and more specifically on the tear film. We performed a longitudinal study to identify a specific proteome of tears before and after corneal abrasion in mice. The corneal abrasion was performed unilaterally on female mice. Tear fluid samples were collected from the wounded eye and the contralateral eye before corneal abrasion and during the wound healing process up to 24hrs post-abrasion. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-10_09:32:20.549.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Laura Fichter |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-05 00:05:40 | ID requested | |
| ⏵ 1 | 2025-11-10 09:32:21 | announced | |
Publication List
| 10.1186/s11658-025-00804-9; |
| Feret N, Megido AC, Kuony A, Marangoni P, Fichter L, Garcia Llorens S, Attina A, Nhiri N, Jacquet E, Vialaret J, Daien V, David A, Hirtz C, Loulier K, Klein OD, Michon F, Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism. Cell Mol Biol Lett, 30(1):131(2025) [pubmed] |
Keyword List
| submitter keyword: epithelium, proteomics,cornea, lacrimal gland, epitranscriptomics, tears, transcriptomics |
Contact List
| Frédéric Michon |
|---|
| contact affiliation | Institute for Neurosciences of Montpellier, Univ Montpellier, INSERM, Montpellier, France |
| contact email | frederic.michon@inserm.fr |
| lab head | |
| Laura Fichter |
|---|
| contact affiliation | Plateforme de Protéomique Clinique, CHU de Montpellier |
| contact email | l-fichter@chu-montpellier.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD061492 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061492
- Label: PRIDE project
- Name: Decoding the molecular complexity governing corneal wound closure in vivo
