PXD061485-1

PXD061485 is an original dataset announced via ProteomeXchange.

Title	Tandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice
Description	Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal condition characterized by premature aging with an average age of death of 14.5 years. Patients with HGPS age at a rate 5 to 10 times faster than normal individuals and are thought to undergo an accelerated version of normal aging.To investigate the mechanisms of HGPS aging, we performed tandem mass tag (TMT) proteomics sequencing analysis on lung tissues from 12-week-old wild-type Lmna+/+ mice and LmnaG609G/G609G mice.Of the upregulated proteins, the Ca2+-binding protein S100A6 was found to be significantly upregulated in the lung tissue of LmnaG609G/G609G mice.
HostingRepository	PRIDE
AnnounceDate	2026-05-16
AnnouncementXML	Submission_2026-05-15_21:07:32.644.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	weifang Xiang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-04 22:15:49	ID requested
⏵ 1	2026-05-15 21:07:33	announced

Dataset with its publication pending

submitter keyword: S100A6,Mouse, LmnaG609G/G609G mice, HGPS

Yu Zhang
contact affiliation	Key Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University, Changchun, China.
contact email	zhangy288@nenu.edu.cn
lab head
weifang Xiang
contact affiliation	Key Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University
contact email	xiangwf982@nenu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD061485

PRIDE project URI

• PRIDE
  1. PXD061485
     1. Label: PRIDE project
     2. Name: Tandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice