PXD061466-1

PXD061466 is an original dataset announced via ProteomeXchange.

Title	Non-allosteric Inhibition of Enolase 1 Impedes Growth of Triple-Negative Breast Cancer
Description	1. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 cells were treated for 6h with DMSO or SU212 and incubated at different temperatures and protein differences in the soluble fractions were determined. 2. Quantitative Proteomics: MDA-MB-231, MDA-MB-468, and BT549 cells were treated with DMSO (vehicle control) or SU212 (novel small molecule drug candidate). Quantitative proteomics analysis was performed on cell lysates.
HostingRepository	PRIDE
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_13:36:21.881.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sharon Pitteri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-04 10:54:01	ID requested
⏵ 1	2025-10-10 13:36:22	announced

Dataset with its publication pending

submitter keyword: Non-Allosteric Inhibition, ENO1, Aza-podophyllotoxin derivative,Enolase, triple-negative breast cancer

Sharon Pitteri
contact affiliation	Department of Radiology Stanford School of Medicine Stanford University
contact email	spitteri@stanford.edu
lab head
Sharon Pitteri
contact affiliation	Stanford University
contact email	spitteri@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD061466

PRIDE project URI

• PRIDE
  1. PXD061466
     1. Label: PRIDE project
     2. Name: Non-allosteric Inhibition of Enolase 1 Impedes Growth of Triple-Negative Breast Cancer