PXD061427-1

PXD061427 is an original dataset announced via ProteomeXchange.

Title	Characterisation of VPRBP/DCAF1 kinase inhibitor analogues
Description	Multiple myeloma is a plasma cell malignancy that is susceptible to drugs targeting protein homeostasis such as thalidomide analogues and proteasome inhibitors. Thalidomide analogues modulate the activity of DDB1/CUL4 E3-ligase complexes to perturb substrate recognition and proteasomal degradation thereof. We hypothesised that the cellular pool of DDB1/CUL4 associated factors (DCAFs) may mediate other essential plasma cell processes and offer new targets for therapeutic intervention. Utilising B32B3, a previously disclosed DCAF1 kinase inhibitor as a template, we developed a series of analogues with enhanced anti-myeloma potency.
HostingRepository	PRIDE
AnnounceDate	2025-10-07
AnnouncementXML	Submission_2025-10-06_18:40:33.272.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD061427
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicole Verrills
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monomethylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-03 21:18:30	ID requested
⏵ 1	2025-10-06 18:40:33	announced

10.6019/PXD061427;

submitter keyword: DCAF1, proteomics, myeloma

Nikki Verrills
contact affiliation	School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, and Precision Medicine Research Program, Hunter Medical Research Institute, NSW, 2308, Australia
contact email	Nikki.Verrills@newcastle.edu.au
lab head
Nicole Verrills
contact affiliation	School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine, University of Newcastle, and Cancer Research Program, Hunter Medical Research Institute, Callaghan, NSW, 2308, Australia
contact email	nikki.verrills@newcastle.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD061427
     1. Label: PRIDE project
     2. Name: Characterisation of VPRBP/DCAF1 kinase inhibitor analogues