PXD061405 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner |
| Description | Inducing cardiomyocyte proliferation in situ presents a promising approach for cardiac regeneration following myocardial injury; however, mature cardiomyocytes exhibit inhibitory mechanisms that suppress proliferative signaling. This study investigates the role of cell-cell contact as a key regulator of cardiomyocyte proliferation. Using human iPSC-derived cardiomyocytes (hiPSC-CMs), the findings demonstrate that proliferation initially increases with cell density but is markedly suppressed upon the establishment of intercellular contacts. Phosphoproteomic and phenotypic analyses reveal that cell-cell contact promotes adherens junction formation, enhances sarcomere organization, and increases contractility, collectively contributing to the suppression of proliferation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-15 |
| AnnouncementXML | Submission_2025-12-15_02:35:21.332.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sean Humphrey |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-03 08:39:41 | ID requested | |
| ⏵ 1 | 2025-12-15 02:35:22 | announced | |
Publication List
| 10.1161/circresaha.125.326522; |
| Lee S, Heinrich P, Lee D, Kang Y, Robinson HR, Humphrey SJ, Yun J, Goodyer WR, Buikema JW, Paik DT, Galdos FX, Kim B, Belbachir N, Min S, Cho SW, Lee J, Moretti A, Wu JC, Hudson JE, Wu SM, IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner. Circ Res, 137(10):1279-1291(2025) [pubmed] |
Keyword List
| submitter keyword: cardiac regeneration, cardiac, iPSC, iPSCs, cardiomyocyte, cell proliferation,human, IGFBP2 |
Contact List
| Sean Humphrey |
|---|
| contact affiliation | Murdoch Children's Research Institute, Melbourne, Australia |
| contact email | sean.humphrey@mcri.edu.au |
| lab head | |
| Sean Humphrey |
|---|
| contact affiliation | Murdoch Children's Research Institute |
| contact email | sean.j.humphrey@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD061405 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061405
- Label: PRIDE project
- Name: IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner
