PXD061373-1

PXD061373 is an original dataset announced via ProteomeXchange.

Title	PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
Description	MDA-MB-231 cells with expression of Flag-GPX4 were treated with IFNg. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
HostingRepository	iProX
AnnounceDate	2025-03-01
AnnouncementXML	Submission_2025-05-14_21:21:27.964.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peixiang Zheng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	4800 Plus MALDI TOF/TOF; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-02 20:13:42	ID requested
⏵ 1	2025-05-14 21:21:29	announced

Zheng P, Hu Z, Shen Y, Gu L, Ouyang Y, Duan Y, Ji G, Dong B, Lin Y, Wen T, Tian Q, Hou Y, Zhou Q, Sun X, Chen X, Wang KL, Luo S, Wu S, Sun Y, Li M, Xiao L, Wu Q, Meng Y, Liu G, Wang Z, Bai X, Duan S, Ding Y, Bi Y, Wang Y, Li G, Liu X, Lu Z, Wu X, Tang Z, Xu D, PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation. Nat Chem Biol, 21(9):1420-1432(2025) [pubmed]

submitter keyword: PSAT1, GPX4, ferroptosis, Lipid ROS, cancer immunotherapy

Daqian Xu
contact affiliation	Zhejiang university
contact email	xudaqian@zju.edu.cn
lab head
Peixiang Zheng
contact affiliation	Zhejiang university
contact email	peixiangzheng7@gmail.com
dataset submitter

iProX dataset URI