PXD061290-1

PXD061290 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Discovery of novel CRBN ligands by virtual screening and biological evaluation against multiple hematological cancer cell lines
Description	Immunomodulatory drugs, functioning as cereblon (CRBN) E3 ligase ligands, have been approved for treating various hematological malignancies by hijacking the function of CRBN E3 ligase and inducing the degradation of multiple CRBN-associated substrates. However, the inevitable emergence of drug resistance, resulting from their skeletal similarity, and hematological toxicities pose significant obstacles to their clinical effectiveness. In this study, we report the development of a series of novel CRBN binding moieties, envisioned as a simple deletion of the methylene in isoindole cores of lenalidomide.
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:49:13.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pengyun Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-27 17:50:56	ID requested
⏵ 1	2025-10-12 16:49:14	announced

Publication List

Wei T, Wei P, Wang Y, Mao Y, Yan J, Hu X, Qi Z, Cai X, Jia C, Zhao Z, Li B, Qiao M, Zou Y, Yang T, Sun S, Feng X, Li P, Shang H, Zheng Z, Discovery and Characterization of Novel IKZF1/3 Glue Degraders against Multiple Hematological Cancer Cell Lines. Oncol Res, 33(10):2981-3006(2025) [pubmed]
10.32604/or.2025.065123;

Wei T, Wei P, Wang Y, Mao Y, Yan J, Hu X, Qi Z, Cai X, Jia C, Zhao Z, Li B, Qiao M, Zou Y, Yang T, Sun S, Feng X, Li P, Shang H, Zheng Z, Discovery and Characterization of Novel IKZF1/3 Glue Degraders against Multiple Hematological Cancer Cell Lines. Oncol Res, 33(10):2981-3006(2025) [pubmed]

10.32604/or.2025.065123;

Keyword List

submitter keyword: Hematological cancer
IMiDs
CRBN ligands
molecular docking
antitumor evaluation

submitter keyword: Hematological cancer

IMiDs

CRBN ligands

molecular docking

antitumor evaluation

Contact List

Pengyun Li
contact affiliation	Beijing Institute of Pharmacology and Toxicology
contact email	bnuhuaxuelpy@163.com
lab head
Pengyun Li
contact affiliation	Beijing Institute of Pharmacology and Toxicology
contact email	bnuhuaxuelpy@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD061290
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD061290

PRIDE project URI

Repository Record List

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