PXD061261-1

PXD061261 is an original dataset announced via ProteomeXchange.

Title	ASO-treated Shank3 KO mice phosphoproteome
Description	Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucleotide ASO against Slc6a20a, we sought to modulate NMDAR function in well-established models of psychiatric disorders Shank2 and Shank3 mutant mice.
HostingRepository	PRIDE
AnnounceDate	2026-04-24
AnnouncementXML	Submission_2026-04-24_02:33:56.980.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junyeop Roh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-27 01:00:09	ID requested
⏵ 1	2026-04-24 02:33:57	announced

Dataset with its publication pending

submitter keyword: Slc6a20a,ASO, Shank3 KO

Eunjoon Kim
contact affiliation	IBS, KAIST
contact email	kime@kaist.ac.kr
lab head
Junyeop Roh
contact affiliation	IBS Institute for Basic Science
contact email	droh1028@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD061261

PRIDE project URI

• PRIDE
  1. PXD061261
     1. Label: PRIDE project
     2. Name: ASO-treated Shank3 KO mice phosphoproteome