PXD061183-1

PXD061183 is an original dataset announced via ProteomeXchange.

Title	Proteomic investigation of thyroid aging and pathogenesis reveals health and disease in thyroid cancers.
Description	Understanding thyroid aging is essential for deciphering its physiological and pathological alterations, yet the causal relationship between aging and thyroid disease remains poorly characterized. We conducted a comprehensive proteomic analysis of 6109 thyroid tissues across ages 8-87 from 22 clinical centers (retrospective and prospective cohorts). Using a machine learning-based biological aging clock, we quantified accelerated aging phenotypes in pathological tissues, including benign and malignant nodules. We identified linear and non-linear age-associated proteins and pathways related to metabolism, immune response, and extracellular matrix organization remodeling, with critical transitions observed during the third, sixth, and eighth decades. Cross-species analysis of mouse and monkey tissues uncovered conserved aging markers. Intervention studies suggested that low-protein diets delay thyroid aging in mice, and therapeutic drug screening identified potential anti-tumor candidates. This study establishes the first organ-specific thyroid aging clock, linking tumorigenesis to accelerated aging, and proposing dietary interventions for thyroid longevity.
HostingRepository	PRIDE
AnnounceDate	2025-11-12
AnnouncementXML	Submission_2025-11-12_14:08:30.419.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tiannan Guo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-25 08:10:29	ID requested
⏵ 1	2025-11-12 14:08:31	announced

Dataset with its publication pending

submitter keyword: Aging clock, Drug targets, Metabolic and mitochondrial function, Proteomics, Aging biomarkers,Thyroid nodules, Intervention

Tiannan Guo
contact affiliation	The Guomics Laboratory for Proteome Complexity Science, School of Medicine, School of Life Sciences, Westlake University，Shilongshan Road No.18, Cloud Town, Xihu District, Hangzhou, Zhejiang, China.
contact email	guotiannan@westlake.edu.cn
lab head
Tiannan Guo
contact affiliation	Westlake University
contact email	guotiannan@westlake.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD061183

PRIDE project URI

• PRIDE
  1. PXD061183
     1. Label: PRIDE project
     2. Name: Proteomic investigation of thyroid aging and pathogenesis reveals health and disease in thyroid cancers.