PXD061142-1

PXD061142 is an original dataset announced via ProteomeXchange.

Title	Proteomic comparison of adipose tissue from obese insulin resistant subjects with obese insulin sensitive subjects
Description	Tissues were collected during the Amsterdam (Netherlands) study of Carbohydrate Regulation of Lipid Metabolism ("SODA").  Subjects were divided between those with and without Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD); subjects were further divided by insulin resistance as assessed by hyperinsulinemic-euglycemic clamp.  Prior to bariatric surgery, subjects were given a glucose or fructose drink.  Subcutaneous and omental adipose tissues were collected during bariatric surgery.  Proteomic data was collected from both subcutaneous and omental adipose tissue; and from subjects given either carbohydrate drink (fructose or glucose).
HostingRepository	PRIDE
AnnounceDate	2026-01-26
AnnouncementXML	Submission_2026-01-25_16:20:07.232.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD061142
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Gassaway
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-24 10:10:56	ID requested
⏵ 1	2026-01-25 16:20:08	announced

10.2337/db25-0488;

10.6019/PXD061142;

Strober JW, Ter Horst KW, Sung D, Jongejan A, Slusher AL, Gassaway BM, Tarabra E, Paulo JA, Shuken SR, Gygi SP, Santoro N, Caprio S, Serlie MJ, Bogan JS, Vatner DF, Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue. Diabetes, 75(2):341-350(2026) [pubmed]

submitter keyword: insulin resistance,White adipose tissue, visceral adipose, subcutaneous adipose, insulin action

Steven Gygi
contact affiliation	Department of Cell Biology, Harvard Medical School
contact email	steve_gygi@hms.harvard.edu
lab head
Brandon Gassaway
contact affiliation	Brigham Young University
contact email	brandon.gassaway@byu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD061142

PRIDE project URI

• PRIDE
  1. PXD061142
     1. Label: PRIDE project
     2. Name: Proteomic comparison of adipose tissue from obese insulin resistant subjects with obese insulin sensitive subjects