PXD061057-1

PXD061057 is an original dataset announced via ProteomeXchange.

Title	Identification of SORL1 Binding Partners via Immunoprecipitation-Mass Spectrometry in THP-1 Cells.
Description	SORL1 (Sortilin-Related Receptor 1) is a key player in endosomal trafficking and has been implicated in neurodegenerative disorders. To identify SORL1 binding partners, we performed immunoprecipitation (IP) of SORL1, followed by mass spectrometry-based proteomic analysis. THP-1 cell lysates were used as the source material for immunoprecipitation, and IgG controls were included to filter out non-specific interactions. The resulting datasets provide insights into SORL1-associated protein complexes, offering potential targets for further functional studies.
HostingRepository	PRIDE
AnnounceDate	2026-04-13
AnnouncementXML	Submission_2026-04-12_16:28:08.946.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rajesh Soni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-21 08:03:29	ID requested
⏵ 1	2026-04-12 16:28:10	announced

10.1007/s00401-026-03002-9;

Haq I, Ngo JC, Roy N, Lee E, Choudhury MA, Soni RK, Teich AF, Mayeux RP, De Jager PL, He Y, Wu X, Bennett DA, Olah M, Sher F, Alzheimer's disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons. Acta Neuropathol, 151(1):(2026) [pubmed]

submitter keyword: Alzheimer’s disease, protein-protein interaction, SORL1, microglia, genetics

Falak Sher
contact affiliation	Assistant Professor of Neurological Sciences Columbia University
contact email	fs2644@cumc.columbia.edu
lab head
Rajesh Soni
contact affiliation	Columbia University Medical center
contact email	rs3869@cumc.columbia.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD061057

PRIDE project URI

• PRIDE
  1. PXD061057
     1. Label: PRIDE project
     2. Name: Identification of SORL1 Binding Partners via Immunoprecipitation-Mass Spectrometry in THP-1 Cells.