PXD060921 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HCMV infection mitigate the ability of placental EVs to potentiate neurogenesis by altering their miRNA landscape |
| Description | Human cytomegalovirus (HCMV) is the most common virus transmitted in utero and a leading cause of infectious brain malformations and deafness, yet prognosis methods remain unreliable. Although certain central nervous system lesions caused by HCMV are explained, the neuropathogenesis of congenital infection remains poorly understood. The placenta, a key target of HCMV, plays a critical role during infection due to its involvement in maternal-fetal exchanges, particularly via the secretion of extracellular vesicles (EVs). Placental EVs mediate maternal-fetal communication, carrying proteins and RNAs, including microRNAs, that influence placental function, maternal immune tolerance, and viral defense. Our study explored the effects of placental EVs on fetal neural stem cell phenotype, demonstrating that EVs secreted from HCMV-infected placenta alter neurogenesis. Analysis of EV microRNA profiles revealed infection-induced alterations with predicted interference in brain development pathways. These findings highlight the critical role of placental EVs in fetal brain development and their contribution to HCMV neuropathogenesis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-02 |
| AnnouncementXML | Submission_2026-02-01_16:56:46.667.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Etienne Coyaud |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | carbamoylated residue; acetylated residue; monohydroxylated residue |
| Instrument | timsTOF fleX |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-18 10:13:08 | ID requested | |
| ⏵ 1 | 2026-02-01 16:56:47 | announced | |
Publication List
| 10.1002/jex2.70108; |
| Martin C, Martin H, Bergamelli M, Lobjois L, Franco L, Bordes E, Benchoua A, Balor S, Kantar D, Coyaud E, Martins F, Favereaux A, Malnou CE, Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection. J Extracell Biol, 5(1):e70108(2026) [pubmed] |
Keyword List
| submitter keyword: whole proteome analysis, HCMV,EV, neuronal differentiation |
Contact List
| Etienne Coyaud |
|---|
| contact affiliation | Univ.Lille, CHU Lille, Inserm U1192, Protéomique Réponse Inflammatoire Spectrométrie de Masse (PRISM), Lille, France |
| contact email | etienne.coyaud@inserm.fr |
| lab head | |
| Etienne Coyaud |
|---|
| contact affiliation | Univ. Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France |
| contact email | etienne.coyaud@inserm.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060921
- Label: PRIDE project
- Name: HCMV infection mitigate the ability of placental EVs to potentiate neurogenesis by altering their miRNA landscape
