PXD060820-1

PXD060820 is an original dataset announced via ProteomeXchange.

Title	MULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK
Description	Many polyphenols, such as hydroxytyrosol (HT), have been recognized for their antioxidant and cardiovascular (CV) health benefits. To address the efficacy of HT, the present study aimed to identify the relevant mechanisms, associated with high-CV risk. Plasma unbiased multi-omics data were compared among two subgroups -HT responders and non-responders patients- and in a mice model. Lipid metabolism and proteomic responses were heterogeneous within two distinct ̶ responder and non-responder ̶ subgroups, associated mainly with thrombotic and hemostatic signals. The correlations between classical CV biomarkers, proteins, and metabolites offer a more comprehensive representation of the glutathione and coagulation pathways affected by HT treatment.
HostingRepository	PRIDE
AnnounceDate	2025-07-01
AnnouncementXML	Submission_2025-07-01_09:24:44.021.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sander Piersma
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-14 05:31:41	ID requested
⏵ 1	2025-07-01 09:24:44	announced

10.1039/D5FO00874C;

submitter keyword: Human plasma, Hydroxytyrosol, mouse EV enriched plasma

Dr Connie Ramona Jimenez
contact affiliation	OncoProteomics Laboratory, Dept of Medical Oncology, Amsterdam University Medical Center, Amsterdam, The Netherlands
contact email	C.jimenez@amsterdamumc.nl
lab head
Sander Piersma
contact affiliation	Amsterdam UMC
contact email	s.piersma@amsterdamumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD060820

PRIDE project URI

• PRIDE
  1. PXD060820
     1. Label: PRIDE project
     2. Name: MULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK