PXD060819 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Heterooligomerisation is a conserved feature of eukaryotic typical 2-Cys peroxiredoxins |
| Description | Peroxiredoxins are conserved thiol peroxidases for peroxide detoxification, redox signaling, and chaperone activity. Peroxiredoxin 1-type typical 2-Cys peroxiredoxins are present in both prokaryotes and eukaryotes, with multiple closely related isoforms often coexisting within the same subcellular compartment of a given species. While these peroxiredoxins have long been thought to form exclusively homooligomeric structures, emerging evidence challenges this view. We show that the formation of enzymatically active heterooligomers is a conserved feature of typical 2-Cys peroxiredoxins in eukaryotes and plays an important role in modulating peroxiredoxin oligomeric state. We used negative strain electron microscopy to visualize yeast Tsa1–Tsa2 peroxiredoxin heterodecamers and show that heterooligomer formation is inducible in response to oxidative stress. Our findings suggest that hetero oligomerization is a novel key regulatory mechanism for redox homeostasis and cellular adaptation, reshaping the structural and functional landscape of peroxiredoxins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-11 |
| AnnouncementXML | Submission_2026-03-11_04:13:21.931.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Didier Vertommen |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: NEWT:562; scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932; |
| ModificationList | monohydroxylated residue |
| Instrument | Orbitrap Fusion Lumos; ultraflex |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-14 05:02:20 | ID requested | |
| ⏵ 1 | 2026-03-11 04:13:22 | announced | |
Publication List
Keyword List
| submitter keyword: heterooligomers, eukaryotes, redox homeostasis,Peroxiredoxins |
Contact List
| Joris Messens |
|---|
| contact affiliation | VIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium |
| contact email | joris.messens@vub.be |
| lab head | |
| Didier Vertommen |
|---|
| contact affiliation | UCL - de Duve Institute, Brussels Belgium |
| contact email | didier.vertommen@uclouvain.be |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD060819 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060819
- Label: PRIDE project
- Name: Heterooligomerisation is a conserved feature of eukaryotic typical 2-Cys peroxiredoxins
