PXD060810 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Unveiling Diagnostic Biomarkers in Autism: Comparative Proteome Analysis of CNTNAP2 Knockout Mice and Human ASD Patients |
| Description | This study identifies conserved protein biomarkers for Autism Spectrum Disorder (ASD) using a cross-species proteomic approach. Proteomic analyses were conducted on serum and brain samples from CNTNAP2 knockout (KO) mice and human ASD patient serum. A total of 132 conserved proteins were identified, with functional enrichment in lipid metabolism, synaptic signaling, and immune response. Machine learning refined these to ten key proteins demonstrating high classification performance. This dataset supports the discovery of ASD biomarkers with potential clinical applications. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-23_06:54:10.345.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Eugene C Yi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-14 03:00:19 | ID requested | |
| ⏵ 1 | 2026-02-23 06:54:10 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Machine Learning, Mass Spectrometry, CNTNAP2 Knockout Mouse, Cross-Species Comparison,Autism Spectrum Disorder (ASD), Proteomics, Biomarkers |
Contact List
| eugene c. yi |
|---|
| contact affiliation | seoul national university |
| contact email | euyi@snu.ac.kr |
| lab head | |
| Eugene C Yi |
|---|
| contact affiliation | Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University, Republic of Korea |
| contact email | euyi@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD060810 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060810
- Label: PRIDE project
- Name: Unveiling Diagnostic Biomarkers in Autism: Comparative Proteome Analysis of CNTNAP2 Knockout Mice and Human ASD Patients
