PXD060735 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice |
| Description | Chronic sleep insufficiency is prevalent in modern society and has been associated with age-related neurodegenerative diseases. Loss of sleep accelerates the progression of neurodegeneration in animal models of neurological diseases. Here, we study whether chronic sleep curtailment leads to brain aging in wild-type animals without a genetic predisposition. To this aim, we used a wild-type mouse model to simulate the modern-day condition of restricted sleep and compared the brain (cortex) proteome of young sleep-restricted animals with different aged control groups. We reported the alteration of 149 proteins related to sleep and 1269 related to age with 96 proteins common between them. Through pathway analysis of proteins common to sleep and aging, it was discovered that the complement and coagulation cascade pathways were enriched by alterations of complement component 3 (C3), alpha-2-macroglobulin (A2M), fibrinogen alfa and beta chain (FGA and FGB). This is the first study indicating the possible role of the complement and coagulation pathways in brain aging mediated by chronic sleep restrictions (CSR) in mice. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-10 |
| AnnouncementXML | Submission_2025-12-10_06:00:53.482.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060735 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Pawan Jha |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-12 11:34:03 | ID requested | |
| ⏵ 1 | 2025-12-10 06:00:54 | announced | |
Publication List
Keyword List
| submitter keyword: Chronic Sleep deprivation, Complement system, Brain Aging,Aging, Sleep, Proteomics |
Contact List
| Akhilesh B. Reddy |
|---|
| contact affiliation | Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
| contact email | areddy@cantab.net |
| lab head | |
| Pawan Jha |
|---|
| contact affiliation | Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA |
| contact email | kj.pawan@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD060735 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060735
- Label: PRIDE project
- Name: Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice
