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PXD060697-1
PXD060697 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Evaluation of the activity of monensin and its analogs in triple negative breast cancer cells |
| Description | This project aimed to identify key proteins dysregulated by monensin and itssynthetic analog, compound 12, in the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Byanalyzing the molecular changes induced by these compounds, the study sought to elucidate themechanisms underlying their cytotoxic effects on breast cancer cells. Additionally, it explored potentialdifferences in the activity and efficacy of monensin and compound 12, providing critical insights into theirdistinct biological impacts. These findings may contribute to the development of targeted therapeuticstrategies for triple-negative breast cancer, a highly aggressive and treatment-resistant subtype of breastcancer |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-30 |
| AnnouncementXML | Submission_2026-03-29_16:44:46.682.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060697 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kalyani Dhusia |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-11 12:55:07 | ID requested | |
| ⏵ 1 | 2026-03-29 16:44:47 | announced |
Publication List
| Urbaniak A, Heflin B, Siegel ER, Seale D, Reed MR, Nix JS, Yee EU, J, ę, drzejczyk M, Klejborowska G, St, ę, pczy, ń, ska N, Huczy, ń, ski A, Nagalo BM, Chambers TC, Post SR, Eoff RL, MacNicol MC, Tiwari AK, Kelly T, Tackett AJ, MacNicol AM, Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models. ACS Pharmacol Transl Sci, 8(11):3965-3983(2025) [pubmed] |
| 10.6019/PXD060697; |
| 10.1021/acsptsci.5c00296; |
Keyword List
| submitter keyword: Breast cancer metastasis, Breast cancer,Monensin, Anti-metastatic agents |
Contact List
| Alicja Urbaniak, M.Sc., Ph.D., Ph.D. | |
|---|---|
| contact affiliation | Instructor Department of Biochemistry and Molecular Biology University of Arkansas for Medical Sciences |
| contact email | AUrbaniak@uams.edu |
| lab head | |
| Kalyani Dhusia | |
| contact affiliation | University of Arkansas Medical Sciences |
| contact email | kdhusia@uams.edu |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD060697 |
| PRIDE project URI |
Repository Record List
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