PXD060684 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Abemaciclib differentially reshapes the immunopeptidome of breast cancer subtypes |
| Description | The cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) Abemaciclib has demonstrated transformative potential in the treatment of hormone receptor-positive (HR+) breast cancer. Beyond its established role in cell cycle arrest, we reveal its capacity to enhance tumor immunogenicity by remodeling the immunopeptidome. Using a proteogenomic approach, we analyzed the antigenic repertoire of HR+ and triple-negative breast cancer (TNBC) models following Abemaciclib treatment. Our findings highlight a substantial increase in MHC-I presentation and antigen diversity, particularly in HR+ cells. This effect is mediated through Rb-dependent transcriptional and epigenetic reprogramming involving bromodomain and extraterminal (BET) proteins. Furthermore, we identified novel abemaciclib-induced neoantigens derived from allegedly non-coding genomic regions with therapeutic potential for CDK4/6i-combinational immunotherapies. Our data provide a molecular rationale for the superior efficacy of Abemaciclib in HR+ breast cancers. They also suggest that treatment with Abemaciclib could synergize with immunotherapies targeting CDK4/6i-induced tumor antigens. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-25 |
| AnnouncementXML | Submission_2026-02-25_06:59:36.270.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060684 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Eric Bonneil |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue |
| Instrument | LTQ FT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-11 07:47:18 | ID requested | |
| ⏵ 1 | 2026-02-25 06:59:37 | announced | |
Publication List
| 10.6019/PXD060684; |
| Minati R, Cahuzac M, Perrault J, Lullier V, Apavaloaei A, Bonneil E, Courcelles M, Lanoix J, Kina E, Perreault C, Thibault P, CDK4/6 inhibition reprograms the breast cancer immunopeptidome via Rb-dependent chromatin and transcriptomic remodeling. Cell Rep, 44(12):116676(2025) [pubmed] |
| 10.1016/j.celrep.2025.116676; |
Keyword List
| submitter keyword: breast cancer,Abemaciclib, tumor antigens, mass spectrometry, cancer immunotherapy, immunopeptidomics |
Contact List
| Pierre Thibault |
|---|
| contact affiliation | IRIC-Université de Montréal |
| contact email | pierre.thibault@umontreal.ca |
| lab head | |
| Eric Bonneil |
|---|
| contact affiliation | Proteomic Platform |
| contact email | eric.bonneil@umontreal.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD060684 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060684
- Label: PRIDE project
- Name: Abemaciclib differentially reshapes the immunopeptidome of breast cancer subtypes
