PXD060637 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic and phosphoproteomics analysis of triple combination therapy in cystic fibrosis |
| Description | Trikafta, a CFTR modulator, is increasingly used to treat children with cystic fibrosis (CF), but its effects remain unclear. This study evaluated the cellular mechanisms of Trikafta in young children (< 11 years) with CF using a multi-omic approach. Seventeen children with CF (median age 8.4 years, 29% female) and 12 healthy controls (median age 9.6 years, 42% female) were included. Multi omics analysis including RNA sequencing, proteomics and phosphoproteomics was performed. The proteomic and phosphoproteomics data and search results a provided here. The overall results are discussed in the associated publication. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-04 |
| AnnouncementXML | Submission_2026-08-03_16:50:48.444.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD060637 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Mark Graham |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-10 08:25:28 | ID requested | |
| ⏵ 1 | 2026-08-03 16:50:49 | announced | |
Publication List
Keyword List
| submitter keyword: therapeutics, drug,cystic fibrosis, phosphorylation |
Contact List
| Russell Dale |
|---|
| contact affiliation | Kids Neuroscience Centre |
| contact email | russell.dale@health.nsw.gov.au |
| lab head | |
| Mark Graham |
|---|
| contact affiliation | Children's Medical Research Institute |
| contact email | mgraham@cmri.org.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060637 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060637
- Label: PRIDE project
- Name: Proteomic and phosphoproteomics analysis of triple combination therapy in cystic fibrosis
