PXD060544-1

PXD060544 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Description	Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals a unique mechanism whereby two molecular glues assemble into a helix-like structure and drive ternary complex formation by mimicking a protein degron in trans.
HostingRepository	PRIDE
AnnounceDate	2025-09-08
AnnouncementXML	Submission_2025-09-08_03:17:14.118.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Despoina Kapsitidou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine; acetylated residue
Instrument	timsTOF Ultra

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-06 01:37:00	ID requested
⏵ 1	2025-09-08 03:17:14	announced

Publication List

10.6084/M9.FIGSHARE.29424770;

10.6084/M9.FIGSHARE.29424770;

Keyword List

submitter keyword: Human, Jurkat, DIA, timsTOF Ultra, CRBN

submitter keyword: Human, Jurkat, DIA, timsTOF Ultra, CRBN

Contact List

Debora Bonenfant
contact affiliation	Monte Rosa Therapeutics
contact email	dbonenfant@monterosatx.com
lab head
Despoina Kapsitidou
contact affiliation	Monte Rosa Therapeutics
contact email	dkapsitidou@monterosatx.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD060544
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD060544

PRIDE project URI

Repository Record List

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