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PXD060522-1
PXD060522 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Microbiota-Derived Corisin Accelerates Kidney Fibrosis by Promoting Cellular Aging |
| Description | The increasing global prevalence of diabetic nephropathy poses substantial health and economic burdens. Currently, effective anti-fibrotic therapies for managing kidney fibrosis associated with chronic kidney disease are lacking. This study reveals corisin, a microbiota-derived peptide, as a central driver in the progression of diabetic kidney fibrosis. Corisin levels were found to be markedly elevated in the serum and urine of diabetic chronic kidney disease patients relative to healthy controls, with strong correlations to advanced disease stages and declining renal function. In a murine model of kidney fibrosis, corisin levels were similarly heightened, directly contributing to acute kidney injury and worsening fibrosis and renal impairment. Notably, the use of a monoclonal anti-corisin antibody significantly reduced nephropathy severity in diabetic mice. Through molecular dynamics simulations and experimental validation, we demonstrated that corisin interacts with human serum albumin, potentially enhancing its renal accumulation and pathological impact. The pathogenic mechanism of corisin involves the acceleration of cellular senescence and the induction of epithelial-mesenchymal transition and apoptosis in kidney cells. These findings underscore the critical role of corisin in diabetic nephropathy and suggest a promising new target for therapeutic intervention. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-01-30 |
| AnnouncementXML | Submission_2026-01-29_09:53:53.048.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060522 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Justine Arrington |
| SpeciesList | scientific name: cellular organisms; NCBI TaxID: 131567; |
| ModificationList | unknown modification; alpha-amino acetylated residue; L-methionine sulfoxide |
| Instrument | Orbitrap Fusion ETD |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-05 09:27:05 | ID requested | |
| ⏵ 1 | 2026-01-29 09:53:54 | announced |
Publication List
| Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Toda M, Uemura M, Nishihama K, Takeshita A, Fridman D'Alessandro V, Okano T, Okano Y, Tomaru A, Anoh T, Inoue C, Alhawsawi MAB, Abdel-Hamid AM, Leistikow K, King MR, Ono R, Nosaka T, Yamazaki H, Fields CJ, Mackie RI, Mi X, Shukla D, Arrington J, Yano Y, Hataji O, Kobayashi T, Cann I, Gabazza EC, Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging. Nat Commun, 16(1):7591(2025) [pubmed] |
Keyword List
| submitter keyword: kidney fibrosis, diabetes, corisin |
Contact List
| Esteban C Gabazza, MD PhD; Isaac Cann, MS PhD; Tetsu Kobayashi, MD PhD | |
|---|---|
| lab head | |
| Justine Arrington | |
| contact affiliation | Salk Institute for Biological Studies |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
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