PXD060499-1

PXD060499 is an original dataset announced via ProteomeXchange.

Title	Molecular basis of reproductive plasticity of termite workers under environmental stresses
Description	Eusociality is an important step in animal evolution that increases the level of biological complexity. The reproductive plasticity of termite female workers provides colonies with the tremendous flexibility to respond to environmental (social) stresses. Here, we established an “inhibition-activation-reinhibition” research model of the reproductive transformation of female workers using three Reticulitermes species. We identified the functional genes involved in the transformation process, explaining why the transformation of workers to reproductives in R. aculabialis were not triggered under the same isolation conditions. Transposable elements in the brains of workers promote the transformation of workers into reproductives. The metabolic levels were associated with changes in stress caused by female reproduction and the nest environment. Strikingly, we confirmed that when female workers experience severe environmental stresses that affect their survival, they do not initiate reproductive transformation, even if there is no female reproductive in the nests. Furthermore, based on the regulatory network of molecules, we constructed machine learning models to demonstrate how numerous genes co-regulate the reproductive plasticity of workers and to predict the fertility of colonies. Among these, deep neural network models had the highest prediction accuracy and generalization, indicating that workers carry a wealth of information about their colony at the molecular level. We suggest that combined molecular function and deep learning model analysis for caste differentiation, reproductive plasticity, colony development and adaptation will provide a methodology for revealing complex gene regulatory networks that respond to environmental changes in social insects. Our findings are essential for understanding the reproductive plasticity of humans and other social animals to respond to environmental changes and social stresses.
HostingRepository	iProX
AnnounceDate	2025-01-29
AnnouncementXML	Submission_2025-02-04_22:40:45.814.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaohong Su
SpeciesList	scientific name: Reticulitermes labralis; NCBI TaxID: 141914;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 22:40:19	ID requested
⏵ 1	2025-02-04 22:40:46	announced

Dataset with its publication pending

submitter keyword: metabolomics, termite, reproductive plasticity, LC-MS

Xiaohong Su
contact affiliation	Northwest University
contact email	sxhnwu@nwu.edu.cn
lab head
Xiaohong Su
contact affiliation	Northwest University
contact email	sxhnwu@nwu.edu.cn
dataset submitter

iProX dataset URI