PXD060484-1

PXD060484 is an original dataset announced via ProteomeXchange.

Title	A quantitative spectral library of human aqueous humor was analyzed using TimsTOFTM Pro Bruker for primary open angle glaucoma (POAG).
Description	Globally, irreversible vision loss is mainly attributed to glaucoma, a complex eye condition. Given that the progression of glaucoma is challenging to detect and track, and reliable predictive markers are lacking, there is an urgent need for biomarkers. In this context, the aqueous humor, which is part of the anterior segment of the eye, assumes a critical role. The aim of this study is to develop a comprehensive database for glaucoma research by analyzing primary open-angle glaucoma (POAG) human aqueous humor samples (n=66). We employ advanced label-free quantitative proteomics to investigate the proteome associated with glaucoma in human aqueous humor. Our dataset, generated using the TimsTOF™ Pro Bruker mass spectrometer and DIA-NN bioinformatics for library-independent quantification of data-independent acquisition (DIA) proteomics, offers researchers access to the most extensive catalog of human aqueous humor proteins reported to date. This resource is expected to deepen our understanding of the proteomic profiles in human glaucoma aqueous humor and also support investigations into proteomes related to other ocular conditions.
HostingRepository	PRIDE
AnnounceDate	2025-08-05
AnnouncementXML	Submission_2025-08-05_04:23:29.213.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuen Lam
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 18:20:25	ID requested
⏵ 1	2025-08-05 04:23:29	announced

10.1016/J.DIB.2025.111881;

submitter keyword: POAG, human aqueous humor, primary open-angle glaucoma

Dr Chuen
contact affiliation	School of Optometry, The Hong Kong Polytechnic University, Hong Kong
contact email	cclam@polyu.edu.hk
lab head
Chuen Lam
contact affiliation	The Hong Kong Polytechnic University/School of optometry
contact email	cclam@polyu.edu.hk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060484
     1. Label: PRIDE project
     2. Name: A quantitative spectral library of human aqueous humor was analyzed using TimsTOFTM Pro Bruker for primary open angle glaucoma (POAG).