PXD060437 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics data of plasma and bronchial alveolar lavage fluid collected from Acute respiratory distress syndrome patients |
| Description | Acute respiratory distress syndrome (ARDS) is a severe and complex critical illness, characterized by its heterogeneous clinical presentation, making accurate clinical definition and effective treatment challenging. We hypothesized that advanced molecular analyses of matched plasma and bronchial alveolar lavage fluid (BALF) collected from ICU patients over the time course of their hospitalization could enable the characterization of ARDS subtypes and provide insight into the underlying mechanistic pathways, leading to novel therapeutic strategies. Proteomics and redox proteomics analyses of 32 plasma and 33 BALF specimens from 16 patients collected at serial time points generated extensive data. Applied data analytics revealed defined patient grouping for BALF, featuring distinct proteins and pathways implicated in the pathology of ARDS. Plasma analyses were much less informative. Despite the limited number of patients, this pilot study underscores the value of a molecular approach to the characterization of ARDS. As relevant biomarkers are identified and refined, we anticipate that proteomic signatures differentiating disease severity will equip clinicians with superior diagnostic tools, fostering molecularly informed treatments to ultimately improve patient outcomes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-16 |
| AnnouncementXML | Submission_2026-02-15_23:03:09.509.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060437 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jingyun Lee |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-03 11:28:33 | ID requested | |
| ⏵ 1 | 2026-02-15 23:03:10 | announced | |
Publication List
| Forshaw TE, Shukla K, Wu H, Sergeant S, Lee J, Tsang AW, Morris PE, Gibbs KW, Files DC, Furdui CM, A proteomics and redox proteomics approach to understanding ARDS heterogeneity. Sci Rep, 16(1):6034(2026) [pubmed] |
| 10.1038/s41598-026-35606-2; |
| 10.6019/PXD060437; |
Keyword List
| submitter keyword: ARDS, bronchial alveolar lavage fluid, plasma, redox proteomics,Global proteomics |
Contact List
| Cristina M. Furdui |
|---|
| contact affiliation | Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157 |
| contact email | cfurdui@wakehealth.edu |
| lab head | |
| Jingyun Lee |
|---|
| contact affiliation | Wake Forest University School of Medicine |
| contact email | jilee@wakehealth.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD060437 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060437
- Label: PRIDE project
- Name: Proteomics data of plasma and bronchial alveolar lavage fluid collected from Acute respiratory distress syndrome patients
